膜粘连蛋白-2抗体

This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Function : Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response.
Subunit : Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36. Interacts with ATP1B1 and DYSF. Interacts with human cytomegalovirus (HCMV). Interacts with COCH.
Subcellular Location : Secreted, extracellular space, extracellular matrix, basement membrane. Melanosome. Note=In the lamina beneath the plasma membrane. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Translocated from the cytoplasm to the cell surface through a Golgi-independent mechanism.
Post-translational modifications : Phosphorylation of Tyr-24 enhances heat stress-induced translocation to the cell surface.
ISGylated.
Similarity : Belongs to the annexin family.
Contains 4 annexin repeats.
Database links : UniProtKB/Swiss-Prot: P07355.2
信号传导（Signaling Intermediates）
Annexin 2是新近发现的纤维蛋白溶解酶原(PLG)和组织型纤溶蛋白溶解酶原激活物(t-PA)的共受体,是Ca2+介导具有高亲和力的磷脂结合蛋白.其介导血管内外纤维蛋白溶解,对保持机体内环境稳定具有重要作用.
依赖性膜磷脂结合蛋白Annexin II调控异常及有害因子的作用,可导致血栓性疾病和动脉硬化症
钙依赖性膜磷脂结合蛋白膜粘连蛋白2异常高表达所引起纤溶亢进,是白血病等恶性肿瘤出血合并症重要机制之一.钙依赖性磷脂结合蛋白对其干预和调控可能为治疗上述病症提供新思路,为临床治疗开辟新途径.