Bcl-2同源拮抗剂Bak抗体

编号：XY- 1284R

BCL2-antagonist/killer 1（Bcl2 homologous antagonist/killer; Bak1; Bak; N-Bak; N-BAK1; BCL2-like 7 protein; BCL2L7） belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress.
Function : In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the anti-apoptotic action of BCL2 or its adenovirus homolog E1B 19k protein. Low micromolar levels of zinc ions inhibit the promotion of apoptosis.
Subunit : Belongs to the Bcl-2 family.
Subcellular Location : Mitochondrion membrane.
Tissue Specificity : Expressed in a wide variety of tissues.
Similarity : Belongs to the Bcl-2 family.
Database links : UniProtKB/Swiss-Prot: Q07813.1
Bak属于bcl-2基因家族中的成员，具有抑制凋亡的作用。BAK基因是新发现的细胞凋亡促进因子，BAK含BH1和BH2结构域，其功能类似于BAX；拮抗BCL2、BCL-XL的抗凋亡效应。