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CC趋化因子受体2/5抗体 
CC趋化因子受体2/5抗体
编号 : XY-0562R
品牌 : 1mg/1ml
类型 : 抗体
规格 : 0.1ml/0.2ml
提供正式发票 : 提供
提供合同协议 : 提供
价格 :
0.00
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CC趋化因子受体2/5抗体

This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene. [provided by RefSeq, Mar 2009].
Function : Receptor for the MCP-1, MCP-3 and MCP-4 chemokines. Transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection.
Subunit : Binds to HIV-1 Tat. Interacts with ARRB1.
Subcellular Location : Cell membrane; Multi-pass membrane protein.
Post-translational modifications : N-glycosylated.
Similarity : Belongs to the G-protein coupled receptor 1 family.
Database links : UniProtKB/Swiss-Prot: P41597
CCR-2是属于G蛋白偶联受体一家族,参与调节白细胞的迁移和活性作用,是细胞膜蛋白,它的变异与HIV-1抵抗有关。CCR-2不仅在宫颈癌组织中表达,而且在人其他肿瘤如白血病、淋巴瘤、乳腺癌、肾B 癌、胃癌、结肠癌、肝癌和子宫癌中均有过度表达,可作为肝癌及乳腺癌诊断的标志物。


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