细胞表面趋化因子受体3抗体

The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3(CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants encoding the same protein have been described.
Function : Receptor for a C-C type chemokine. Binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection.
Subunit : Binds to HIV-1 Tat.
Subcellular Location : Cell membrane; Multi-pass membrane protein.
Tissue Specificity : In eosinophils as well as trace amounts in neutrophils and monocytes.
Similarity : Belongs to the G-protein coupled receptor 1 family.
Database links : UniProtKB/Swiss-Prot: P51677.1
趋化因子受体3(CCR3)主要在嗜酸粒细胞，Th2淋巴细胞，肥大细胞，支气管上皮细胞上表达， CCR3介导嗜酸粒细胞内有丝分裂原活化蛋白激酶（MAPK） 细胞外信号调节激酶-2（ERK2）、p38和JNK的活化。