CD3抗体

编号：XY-0765R

The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008].
Function : The CD3 complex mediates signal transduction.
Subunit : The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma, delta, epsilon, zeta, and eta.
Subcellular Location : Membrane; Single-pass type I membrane protein.
Similarity : Contains 1 Ig-like (immunoglobulin-like) domain.
Contains 1 ITAM domain.
Database links : NCBI Reference Sequence: NP_000724
UniProtKB/Swiss-Prot: P07766
CD3 epsilon 参与T淋巴细胞介导,主要用于免疫排斥方面的研究.