CD34抗体（细胞表面的唾液粘蛋白）说明书

Hematopoietic Stem Cell Marker
Endothelial Markers
Tumor biomarkers

The highly glycosylated 75-120 kD antigen CD34 is possibly an adhesion molecule with a putative role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. It could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. CD34 is thought to have a role in presenting carbohydrate ligands to selectins. The intracellular chain of the CD34 antigen is a site of phosphorylation by activated protein kinase C, suggesting a putative role in signal transduction. Two isoforms of CD34 have been reported to be generated by alternative splicing. CD34 is highly expressed on hematopoietic progenitors, as well as on endothelial cells, brain, and testis. Staining for CD34 has been used to measure angiogenesis, which reportedly predicts tumor recurrence.
Function : Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins.
Subcellular Location : Membrane; Single-pass type I membrane protein.
Tissue Specificity : Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues.
Post-translational modifications : Highly glycosylated.
Phosphorylated on serine residues by PKC.
Similarity : Belongs to the CD34 family.
Database links :

造血干细胞标志物
内皮标志物
肿瘤生物标志物

细胞表面的唾液粘蛋白。

间充质干细胞（mesenchymal stem cells,MSC）也是干细胞家族的重要成员，来源于发育早期的中胚层和外胚层。MSC最初在骨髓中发现，因其具有多向分化潜能、造血支持和促进干细胞植入、免疫调控和自我复制等特点。如间充质干细胞在体内或体外特定的诱导条件下，可分化为血管内皮、脂肪、骨、软骨、肌肉、肌腱、韧带、神经、肝、心肌、等多种组织细胞。