CD5抗体

编号：XY- 1113R

CD5 is a 55kDa T lymphocyte single chain transmembrane glycoprotein. It is present on all mature T lymphocytes, on most thymocytes and on many T cell leukemias and lymphomas. It reacts with a subpopulation of activated B cells. CD5/Lyt1 antigen is a monomeric type I transmembrane glycoprotein expressed on thymocytes, T lymphocytes, and a subset of B lymphocytes, but not on natural killer (NK) cells. It has been identified as the major ligand of the B cell antigen CD72. The frequency of CD5+ B cells exhibits strain dependent variation, and the phenotypic, anatomical, functional, developmental, and pathological characteristics of the CD5+ B cells suggest that they may represent a distinct lineage, known as B1 cells. Binding of CD5 on the T cell surface can augment alloantigen or mitogen induced lymphocyte proliferation and induces increased cytosolic free calcium, IL2 secretion, and IL2R expression. It has been proposed that CD5 negatively regulates signal transduction mediated by the T cell and B cell receptors.
Function : May act as a receptor in regulating T-cell proliferation.
Subunit : Interacts with CD72/LYB-2. Interacts with PTPN6/SHP-1.
Subcellular Location : Cell membrane; Single-pass type I membrane protein.
Post-translational modifications : Phosphorylated on tyrosine residues by LYN; this creates binding sites for PTPN6/SHP-1.
Similarity : Contains 3 SRCR domains.
Database links : UniProtKB/Swiss-Prot: P06127.2