神经细胞粘附分子1抗体（Elisa IP IHC 用）

编号：XY- 0736R

NCAM (neural cell adhesion molecule 1; CD56 ) is a cell adhesion molecule involved in neuron-neuron adhesion (through the formation of zipper-like NCAM-complexes), neurite fasciculation, outgrowth of neurites, etc. NCAM is also involved in heterophilic interactions with a number of proteins and extracellular matrix molecules. Some of these heterophilic interactions are mutually exclusive, and some interfere with or are dependent on homophilic NCAM interactions. Furthermore, both homo- and heterophilic interactions are modulated by posttranslational modifications of NCAM. Heterophilic NCAM-interactions initiate several intracellular signal transduction pathways ultimately leading to biological responses involving cellular differentiation, proliferation, migration and survival. It is type I membrane protein.
Function : This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.
Subcellular Location : Secreted and Cell membrane.
Similarity : Contains 2 fibronectin type-III domains.
Contains 5 Ig-like C2-type (immunoglobulin-like) domains.

细胞粘附蛋白（Call Adhesion Protein）
神经元标志物

NCAM-1为神经细胞粘附分子，主要分布于神经组织，神经—肌肉接头，神经—内分泌腺和某些内分泌腺以及大多数神经外胚层来源的细胞、组织和肿瘤中。
NCAM 1主要用于视网膜母细胞瘤、髓母细胞瘤、星形细胞瘤、神经母细胞瘤等肿瘤方面的研究。CD56（神经细胞黏附分子，NCAM）表达于大部分神经外胚层来源的细胞系、组织和肿瘤如视网膜母细胞瘤、成神经管细胞瘤、星形细胞瘤以及成神经细胞瘤。它也表达于一些中胚层来源的肿瘤如横纹肌肉瘤。NK细胞以及NK细胞淋巴瘤为阳性。CD56被认为是NK细胞肿瘤的重要标志物。该抗体识别分子量为180，145和125kDa亚型。