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 L选择素抗体 
 L选择素抗体
品牌 : 1mg/1ml
类型 : 抗体
规格 : 0.1ml/0.2ml
提供正式发票 : 提供
提供合同协议 : 提供
价格 :
0.00
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L选择素抗体

编号:XY- 1036R

This gene encodes a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. The encoded protein contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeats. The gene product is required for binding and subsequent rolling of leucocytes on endothelial cells, facilitating their migration into secondary lymphoid organs and inflammation sites. Single-nucleotide polymorphisms in this gene have been associated with various diseases including immunoglobulin A nephropathy. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009].
Function : Cell surface adhesion protein. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia.
Subunit : Interaction with PSGL1/SELPLG and PODXL2 is required for promoting recruitment and rolling of leukocytes. This interaction is dependent on the sialyl Lewis X glycan modification of PSGL1 and PODXL2, and tyrosine sulfation modifications of PSGL1. Sulfation on 'Tyr-51' of PSGL1 is important for L-selectin binding.
Subcellular Location : Membrane; Single-pass type I membrane protein.
Tissue Specificity : Expressed in B-cell lines and T-lymphocytes.
Similarity : Belongs to the selectin/LECAM family.
Contains 1 C-type lectin domain.
Contains 1 EGF-like domain.
Contains 2 Sushi (CCP/SCR) domains.

属于内皮细胞白细胞粘附分子,主要在淋巴细胞表达,淋巴细胞型选择素。


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