神经生长相关蛋白-43（抗体）说明书

The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Function : This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.
Subunit : Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence.
Subcellular Location : Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, growth cone membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse. Cell projection, filopodium membrane; Peripheral membrane protein. Note=Cytoplasmic surface of growth cone and synaptic plasma membranes.
Post-translational modifications : Phosphorylated at Ser-41 by PHK. Phosphorylation of this protein by a protein kinase C is specifically correlated with certain forms of synaptic plasticity.
Palmitoylation by ARF6 is essential for plasma membrane association and axonal and dendritic filopodia induction. Deacylated by LYPLA2.
Similarity : Belongs to the neuromodulin family.
Contains 1 IQ domain.
Database links : UniProtKB/Swiss-Prot: P17677.1
神经生物学相关蛋白（Neurobiology）；神经标志物
GAP43 （Growth associated protein-43）又称作neuromodulin，是一个轴突膜蛋白，是一种神经特异性的蛋白质，参与神经细胞外生长及突触发育形成和神经细胞再生。在神经元发育和再生过程中以高水平表达。能调解轴突延伸作用，改变细胞形态。作为细胞内信号，可大大增强与G蛋白偶联的受体转运作用。
神经生长相关蛋白-GAP-43和神经细胞黏附因子(neural cell adhesion molecule,NCAM)与突触可塑性密切相关.GAP-43是一种神经细胞膜上的特异性磷蛋白,在神经发育和再生过程中呈现高表达,被作为突触生长的标志物,有称脊髓生长相关蛋白
GAP-43与CaM结合,参与G蛋白相互作用,神经递质的释放,作用于胞吞/胞吐过程,通过小囊溶合或诱导生长锥和突触前末端的胞吞促进膜扩展,与海马长时程增强密切相关.
神经细胞黏附因子是细胞表面糖蛋白大家族的成员之一,促进轴突生长,对长时记忆的保持有重要影响,同时,GAP-43对其具调节作用，广泛而深入地研究GAP-43意义深远。