肠道内富含的Kruppel样因子/上皮锌指蛋白抗体说明书

KLF4 is a transcription factor that works with Sp1 to activate the Laminin gamma1 chain gene. It binds the CACCC core sequence. KLF4 may be involved in the differentiation of epithelial cells and may also function in the development of the skeleton and kidney. KLF4 also has roles as both an oncogene and a tumor suppressor.
Function : Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription.
Subunit : Interacts with POU5F1/OCT4 and SOX2. Interacts with MUC1 (via the C-terminal domain).
Subcellular Location : Nucleus.
Post-translational modifications : Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein.
Similarity : Belongs to the krueppel C2H2-type zinc-finger protein family.
Contains 3 C2H2-type zinc fingers.

Klf4（原称GKLF）调节体外細胞的增生与分化，有学者认为：KLF4可能参与消化系统肿瘤的发生及发展过程，多表达与结肠。又称：上皮锌指转录因子（上皮锌指蛋白）Surface skin layer zinc finger protein。