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 钠氢通道蛋白抗体 
 钠氢通道蛋白抗体
品牌 : 1mg/1ml
类型 : 抗体
规格 : 0.1ml/0.2ml
提供正式发票 : 提供
提供合同协议 : 提供
价格 :
0.00
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钠氢通道蛋白抗体

编号:XY- 0505R

NHE1 ( Na+/H+ Exchanger) is maintains in the cell one of environment main cell membrane protein, its main function is adjusts in the cell the pH value, makes it to maintain in the physiological scope. In the cell the pH value change, is direct or the indirect influence cell growth splits, the multiplication and the differentiation, also affects the cell the death. activeness also affects the cell the migration and the tumor cell shift. At present the main direction is: Research digestive tract tumor cell shift.
Function : Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.
Subunit : Oligomer (By similarity). Interacts with calmodulin and TESC. Interacts (via the juxtamembrane region of the cytoplasmic C-terminus domain) with CHP1; the interaction occurs at the plasma membrane in a calcium-dependent manner. Interacts with CHP2; the interaction occurs in a calcium-dependent manner.
Subcellular Location : Membrane; Multi-pass membrane protein.
Tissue Specificity : Kidney and intestine.
Post-translational modifications : O-glycosylated.
Ubiquitinated, leading to its degradation by the proteasome. Ubiquitination is reduced by CHP1 (By similarity).

Similarity : Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.

通道蛋白(Channel Protein)
钠-氢交换蛋白(NHE: Na+/H+ Exchanger)是维持细胞内环境的主要细胞膜蛋白质之一,它的一个主要功能是调节细胞内pH值,使之保持在生理范围之内。细胞内pH值的变化,直接或间接的影响细胞的生长分裂、增殖和分化,也影响细胞的死亡。
钠-氢交换蛋白质的活性还影响细胞的移动和肿瘤细胞的转移。
目前主要方向是:研究消化道肿瘤细胞转移。


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