钠碘转运体蛋白抗体说明书

catalyzes Na+/I- symporter activity plays a role in iodide transport and thyroid hormone generation.
Human Sodium Iodide Symporter (hNIS) is responsible for iodide concentrating ability within thyroid follicular cells. It is a membrane bound glycoprotein with 13 membrane spanning domains and 14 extramembranous domains. It may represent an autoantigen in thyroid.
Function : Mediates iodide uptake in the thyroid gland.
Subcellular Location : Membrane; Multi-pass membrane protein.
Tissue Specificity : Expression is primarily in thyroid tissue, but also to a lower extent in mammary gland and ovary. Expression is reduced in tumors.
DISEASE : Thyroid dyshormonogenesis 1 (TDH1) [MIM:274400]: A disorder characterized by the inability of the thyroid to maintain a concentration difference of readily exchangeable iodine between the plasma and the thyroid gland, leading to congenital hypothyroidism. Note=The disease is caused by mutations affecting the gene represented in this entry.
Similarity : Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
Database links : UniProtKB/Swiss-Prot: Q92911.1
钠/碘转运体蛋白-NIS，是位于甲状腺细胞基底膜上的一类膜抗原，在甲状腺对碘的主动转运过程中发挥重要作用。
钠/碘转运蛋白受甲状腺刺激素(TSH)、碘、细胞因子和生长因子等多种因素的广泛调节。自身免疫性甲状腺疾病时NIS的表达发生了明显变化，患者体内出现抗NIS自身抗体。
此外，NIS还与甲状腺冷结节和先天性甲状腺机能减退等甲状腺疾病的发病机理密切相关，近年来得到了足够的重视。