(抗原）

编号：XY-0120P

英文名称Acinus peptide

中文名称ACINUS 多肽抗原  

说 明 书0.5mg  1mg  

多肽活性

产品来源

分    类

偶联蛋白

纯化方法

保存条件Store at -20 °C for one year. The lyophilized powder is stable at room temperature for at least one month and for greater than a year when kept at -20°C. Upon reconstituted, aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles.

产品介绍background:

 Chromatin condensation and nuclear fragmentation (CCNF) are the hallmarks of apoptosis. CCNF is triggered by the activation of members of the caspase family, caspase activated DNase (CAD/DFF40), and several novel proteins including AIF and CIDE. A new inducer of chromatin condensation was recently identified and designated Acinus (for apoptotic chromatin condensation inducer in the nucleus). Acinus is cleaved by Caspase 3 and an additional unknown protease generating a small active peptide p17, which causes chromatin condensation in vitro when it is added to purified nuclei. Acinus also induces apoptotic chromatin condensation in cells. Acinus is ubiquitously expressed. Three different spliced forms of Acinus have been identified in human and mouse and designated Acinus L (1341 amino acids), Acinus S (583 amino acids) and Acinus S' (614 amino acids).

 mol wt:67kDa

 Other Aliases:

 ACIN 1; ACIN1; ACINUS; CAN; Apoptotic chromatin condensation inducer 1; Apoptotic chromatin condensation inducer in the nucleus; DKFZp667N107; KIAA0670.