蛋白酶激活受体-1抗原

编号：XY-0828R

英文名称Thrombin receptor

中文名称蛋白酶激活受体-1抗体

别    名SAR; BXR; Proteinase-activated receptor 1 precursor; Thrombin receptor; Coagulation factor II receptor; D15S227E; Prader-Willi/Angelman region-1; PAR1; Coagulation factor II receptor; CF2R; Coagulation factor II (thrombin) receptor; F2R; HTR; PAR 1; PAR1; Protease activated receptor 1; Proteinase activated receptor 1; Thrombin receptor; TR; PAR-1; Coagulation factor II receptor; Coagulation factor II receptor; PAR-1; PAR1_HUMAN; Proteinase activated receptor 1; Proteinase-activated receptor 1.    

说 明 书0.1ml  0.2ml  

研究领域肿瘤  细胞生物  信号转导  激酶和磷酸酶  细胞膜受体  

抗体来源Rabbit

克隆类型Polyclonal

交叉反应Human, Mouse, Rat,

产品应用WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量42kDa

细胞定位细胞膜

性    状Lyophilized or Liquid

浓    度1mg/1ml

免 疫 原KLH conjugated synthetic peptide derived from human PAR1

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMedPubMed

产品介绍:

Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. F2R is a G-protein coupled receptor family member. [provided by RefSeq, Jul 2008]

Function:

High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development.

Subcellular Location:

Cell membrane; Multi-pass membrane protein.

Tissue Specificity:

Platelets and vascular endothelial cells.

Post-translational modifications:

A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand.

Phosphorylated; probably mediating desensitization prior to the uncoupling and internalization of the receptor.

Similarity:

Belongs to the G-protein coupled receptor 1 family.

Gene ID:

2149

Database links:

Entrez Gene: 2149 Human

Omim: 187930 Human

SwissProt: P56488 Baboon

SwissProt: P25116 Human

Unigene: 482562 Human

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

PAR蛋白全称为蛋白酶体活化受体(Protease-activated receptors)，又称：凝血酶受体(Thrombin Receptor)是独立家族的G蛋白偶联受体， 研究认为与炎症，实体肿瘤等密切相关。

PAR1蛋白是乳腺癌细胞侵润和迁移的必需因子，它是作为基质金属蛋白酶体1（MMP-1）的受体关键性作用，这一研究结果为研制新的抗癌药物提供新的靶点。